Uncharted: Drake's Fortune is separated into Chapters. Please click on a Chapter below for appropriate walkthrough help and information on treasures contained within the chapter.
| Chapter 01: Ambushed | Chapter 12: Heading Upriver |
| Chapter 02: The Search for El Dorado | Chapter 13: Sanctuary? |
| Chapter 03: A Surprising Find | Chapter 14: Going Underground |
| Chapter 04: Plane-wrecked | Chapter 15: On the Trail of Treasure |
| Chapter 05: The Fortress | Chapter 16: The Treasure Vault |
| Chapter 06: Unlocking the Past | Chapter 17: The Heart of the Vault |
| Chapter 07: Out of the Frying Pan | Chapter 18: The Bunker |
| Chapter 08: The Drowned City | Chapter 19: Unwelcome Guests |
| Chapter 09: To the Tower | Chapter 20: Race to the Rescue |
| Chapter 10: The Customs House | Chapter 21: Gold and Bones |
| Chapter 11: Trapped | Chapter 22: Showdown |